It depends on what you mean by 'disappeared?'
I'd check census records, death records, the SSDI.
If I had more details, I'd have a better idea of what records would be the most promising.
if you know where he/she was last seen then you could serch that areas death and medical records to find a bit of info.
I am not familiar with your area, however, the Mormon Church has Family History Centers in these locations and they have access to a phenominal amount of information, including local. Also there is an ancestral file on line at familysearch.org that is free to search any time that brings up census records, social security death index, and pedigree info and downloadable gedcoms (pedigree files including family info births,marriages,and deaths, burials). Gedcoms are importable into any genealogical recordkeeping program, many available free on the internet (one at the family search web site,PAF 5.0). Alexandria Louisiana 611 Versailles Blvd Alexandria, Rapides, Louisiana, United States Phone: 318-448-1842 Hours: W 6pm-9pm; Th 10am-5pm; Sat 10am-2pm Closed: 2 weeks over Christmas & New Years. Baker Louisiana 4901 Harding Street Baker, East Baton Rouge, Louisiana, United States Phone: 225-775-0383 Hours: T-Th 9am-1pm, 6pm-9pm; Sat by appt only Closed: Closed November 23-25; December 21-27th . Baton Rouge Louisiana 10335 Highland Road Baton Rouge, East Baton Rouge, Louisiana, United States Phone: 225-769-8913 Hours: T 1pm-3:30pm; W 9am-1pm; Th 4am-7pm,; Sat 9am-12pm Closed: Closed Thanksgiving Week; Christmas closing 2 weeks. Denham Springs Louisiana 25367 Riverton Avenue Denham Springs, Livingston, Louisiana, United States Phone: 225-664-8979 Hours: T-W 9am-12pm, 6:30pm-9pm Gonzales Louisiana 520 Highway 30 Gonzales, Ascension, Louisiana, United States Phone: 225-644-0581 Hours: T 9am-1pm; T-W 6pm-8pm Lafayette Louisiana 116 East Bluebird Drive Lafayette, Lafayette, Louisiana, United States Phone: 337-984-7182 Hours: T 9am-12pm; 7pm-9pm W, Th 7pm-9pm; Monroe Louisiana 33rd & Evangeline Ouachita Parish, Monroe, Louisiana, United States Phone: 318-322-7009 Hours: T 12pm-4pm; Th 12pm-8pm Closed: Thanksgiving Week & 2 weeks for Christmas New Orleans Louisiana 5025 Cleveland Place Metairie, Jefferson, Louisiana, United States Phone: 504-885-3936 Hours: T- W- Th 9am-12pm Closed: Holidays. Opelousas Louisana 430 Plantation Rd Opelousas, St Landry, Louisiana, United States Phone: 337-942-8081 Hours: By appt Ruston Louisiana 205 West Woodhaven Road Ruston, Lincoln, Louisiana, United States Phone: 318-255-8379 Hours: W 6:30pm-8:30pm; Sat 9am-1pm Shreveport Louisiana 200 Carroll Street Shreveport, Caddo, Louisiana, United States Phone: 318-861-6754 Hours: T,W 9am-7pm; 3rd Sat 9am-1pm Closed: Thanksgiving week. 2 weeks from Christmas thru New Years. Slidell Louisiana 112 Rue Esplanade Slidell, St. Tammany, Louisiana, United States Phone: 985-641-3982 Hours: T 10am-2pm, W 9am-3pm Thibodaux Louisiana 3415 Little Bayou Black Drive Houma, Terrebonne, Louisiana, United States Phone: 985-876-0221 Hours: W 7pm-9pm; Also by appointment Winnfield Louisiana 8991 HWY 501 Winnfield, Winn, Louisiana, United States Phone: 318-628-6945 Hours: Th 1pm-9pm
May or Mae Pettibone Hardin was married to the Judge Hardin (outlaw turned judge, apparently characterized in some western movies). She was my great-grandmother's best friend in Harrodsburg, Kentucky. She lived to an old age, in the same home for many years. My great-grandmother would have been her friend in their childhood, which was about 1880 (she was extremely vain, and though she kept meticulous scrapbooks we still have today, she never puts any dates on articles or photos!)
thanks for nothing